Template directed synthesis of antibody Fc conjugates with concomitant ligand release

Viktoriia Postupalenko, ^a Léo Marx, ^b David Viertl, ^cd Nadège Gsponer,^a  Natalia Gasilova, ^e Thibaut Denoel, ^c  Niklaus Schaefer, ^c John O. Prior, ^c Gerrit Hagens, ^a Frédéric Lévy, ^f Patrick Garrouste, ^b Jean-Manuel Segura, ^a and Origène Nyanguile ^a

^a Institute of Life Technologies, HES-SO Valais-Wallis, Sion, Switzerland
^bDebiopharm Research & Manufacturing SA, Martigny, Switzerland
^cDepartment of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
^dIn Vivo Imaging Facility, Department of Research and Training, University of Lausanne, Lausanne, Switzerland
^eEPFL Valais Wallis, MSEAP, ISIC-GE-VS, Sion, Switzerland
^fDebiopharm International SA, Lausanne, Switzerland

Published in Chemical Science, a journal of the Royal Society of Chemistry

https://pubs.rsc.org/en/content/articlelanding/2022/sc/d1sc06182h