[177Lu]Lu-DPI-4452 & [68Ga]Ga-DPI-4452, a new radiopeptide tandem targeting Carbonic Anhydrase IX displays strong theranostic potential in CRC and ccRCC tumors

Presented at SNMMI 2022 Annual Meeting

Norbert Wiedemann¹, Frédéric Massière¹, Franck Brichory¹, Aileen Hoehne², Frank Osterkamp², InêsBorrego¹, Antoine Attinger¹

¹Debiopharm International SA, Lausanne, Switzerland
²3B Pharmaceuticals GmbH, Germany

 

Introduction

• The transmembrane metalloproteaseCarbonic Anhydrase IX (CAIX) represents an attractive diagnostic and therapeutic target in hypoxic solid tumors such as Colorectal Cancer (CRC) and clear cell Renal Cell Carcinoma (ccRCC), with limited expression in healthy organs.
• DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage that can be labelled with different radionuclides for theranostic purposes
• Here we report CAIX expression in CRC and ccRCC human tumorsamples and evaluate for the first time the in vitroand in vivo therapeutic and diagnostic performance of [177Lu]Lu-DPI-4452 and [68Ga]Ga-DPI-4452