Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

Viktoriia Postupalenko, ^a Léo Marx,^b Mathilde Pantin,^b David Viertl,^cd Nadège Gsponer,^a Gaëlle Giudice,^a Natalia Gasilova,^e Margret Schottelius,^cf Frédéric Lévy,^g Patrick Garrouste,^b Jean-Manuel Segura, ^a and Origène Nyanguile ^a

^a Institute of Life Technologies, HES-SO Valais-Wallis, Sion, Switzerland
^bDebiopharm Research & Manufacturing SA, Martigny, Switzerland
^cTranslational Radiopharmaceutical Sciences, Departments of Nuclear Medicine and of Oncology, CHUV/UNIL, Lausanne, Switzerland
^dIn Vivo Imaging Facility, Department of Research and Training, University of Lausanne, Lausanne, Switzerland
^eEPFL Valais Wallis, MSEAP, ISIC-GE-VS, Sion, Switzerland
^fAgora, pôle de recherche sur le cancer, Lausanne, Switzerland
^gDebiopharm International SA, Lausanne, Switzerland

Published in Chemical Science, a journal of the Royal Society of Chemistry

https://pubs.rsc.org/en/content/articlelanding/2022/sc/d1sc06182h