The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNF-alpha-mediated in head and neck squamous cell carcinoma.

O. Matzinger (1), D. Viertl (2), P. Tsoutsou (3), L. Kadi (4), S. Rigotti (4), C. Zanna (4), N. Wiedemann (4), M.C. Vozenin (5), G. Vuagniaux (4), J. Bourhis (2).

Radiother Oncol. 2015 Sep;116(3):495-503. doi: 10.1016/j.radonc.2015.05.017. Epub 2015 Jun 18.

1. Laboratory of Radiation Oncology Department, University Hospital of Lausanne (CHUV), Switzerland; Radiation
2. Oncology Department, Hôpital Riviera-Chablais, Vevey, Switzerland.
3. Laboratory of Radiation Oncology Department, University Hospital of Lausanne (CHUV), Switzerland.
4. Laboratory of Radiation Oncology Department, University Hospital of Lausanne (CHUV), Switzerland; Radiation
5. ncology Department Hôpital du Valais, Sion, Switzerland.
6. Debiopharm International SA, Lausanne, Switzerland.
7. Laboratory of Radiation Oncology Department, University Hospital of Lausanne (CHUV), Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch